Anaphylactic Reaction

Allergic Reaction – Severe

  • Maintain airway
  • Oxygen
  • Epinephrine (1:1000) 0.3 mg (0.3 ml) SQ or IM
  • Consider Albuterol 2.5 mg in 3 ml of 0.9% NaCl every 5 minutes x4 doses
  • Diphenhydramine (Benedryl) 25-50 mg IV/IM
  • Prednisone 60 mg PO
  • Methylprednisolone 125 mg IV
  • Consider Epinephrine (1:10,000) 0.1 mg increments slow IV (1.0 ml diluted in 9 ml 0.9%NaCl) over 5-10 minutes by Online Medical Control Order ONLY

Anaphylactic Reaction – Moderate

  • Maintain airway
  • Oxygen
  • Consider albuterol 2.5 mg in 3 ml 0.9% NaCl via nebulizer every 5 minutes x4 doses
  • Diphenhydramine (Benedryl) 25-50 mg IV/IM
  • Epinephrine (1:1,000) 0.3 mg SQ. Contact medical control if there is a history or risk factors for coronary artery disease

Anaphylactic Reaction – Mild

  • Maintain airway
  • Oxygen
  • Consider diphenhydramine (Benedryl) 25-50 mg PO, IM, IV
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